Open AccessAKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L.
Author(s) -
Novi Anggreini
Publication year - 2018
Publication title -
jurnal farmasi medica
Language(s) - English
Resource type - Journals
eISSN - 2654-640X
pISSN - 2622-9463
DOI - 10.35799/pmj.1.1.2018.19645
Subject(s) - erythrina , chemistry , stereochemistry , traditional medicine , medicine
AKTIVITAS ANTIKANKER SENYAWA PTEROKARPAN DARI Erythrina fusca L. Novi Anggreini1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Natural Products Chemistry Research Group, Organic Chemistry Division,Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesiamulyadi-t@fst.unair.ac.id ABSTRACT Two pterocarpans namely as sandwicensin (1) dan phaseollin (2) were isolated from the stem bark of. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS, 1D and 2D NMR. Compounds 1–2 were evaluated for their anticancer against murin leukemia P-388 cells showing their IC50 were 1.20 and 1.05 µg/ml, respectively and very high activity. Keywords : Erythrina fusca L., sandwicensin, phaseollin, anticancer ABSTRAK Dua senyawa pterokarpan yakni sandwisensin (1) dan paseollin (2) telah diisolasi dari kulit batang Erythrina fusca L. Struktur senyawa pterokarpan ditetapkan berdasarkan analisis spektroskopi UV, IR, MS, 1D dan 2D NMR. Uji aktivitas antikanker senyawa 1–2 terhadap sel murin leukemia P-388 memperlihatkan IC50 1,20 dan 1,05 µg/ml yang dikategorikan sangat aktif. Kata kunci : Erythrina fusca L., sandwisensin, paesolin, antikanker