Hubungan Kadar Interleukin-10 Serum dan Kadar Leukosit Darah Perifer pada Pasien Cedera Otak Berat Akibat Trauma

This study was aimed to prove that in severe traumatic brain injury (TBI) there was an elevation in serum IL-10 level as well as in peripheral blood leukocyte level, and a correlation between both of them. This was an analytical correlational study. All patients had IL-10 level above normal value (18 pg/ml). There were three patients with normal blood leukocyte level. The correlation between IL-10 and blood leukocyte level was tested by using simple linear regression analysis and Pearson correlation coefficient analysis which obtained r = 0.045 with a P of 0.426 (>0.05). These results indicated a positive relationship between IL-10 and leukocytes levels, but not statistically significant. Conclusion: Interleukin-10 was consistantly elevated following severe traumatic brain injury and was a better TBI biomarker than the peripheral leukocyte level.Keywords: IL-10, leukocytes, TBIAbstrak: Penelitian ini bertujuan untuk membuktikan bahwa pada cedera otak akibat trauma (COT) berat terdapat peningkatan kadar serum IL-10 dan kadar leukosit darah perifer serta korelasi antara keduanya. Jenis penelitian ini ialah analitik korelasional. Hasil penelitian mendapatkan 20 pasien dengan COT berat berusia 16-65 tahun. Semua pasien memperlihatkan kadar Il-10 di atas nilai normal (18 pg/ml). Terdapat 3 pasien dengan kadar leukosit dalam batas normal Hubungan antara IL-10 dan leukosit diuji dengan analisis regresi linier sederhana dan analisis koefisien korelasi Pearson dan mendapatkan r = 0,045 dengan P = 0,426. Hasil ini menunjukkan hubungan positif antara IL-10 dan leukosit, tetapi tidak bermakna secara statistik (P = 0,426 >0,05). Simpulan: IL-10 secara konsisten meningkat setelah COT dan sebagai biomarker COT yang lebih baik daripada leukosit perifer.Kata kunci: IL-10, leukosit, COT