Open AccessPERAN SEL STELATA HEPATIK PADA SIROSIS HEPATIS
Author(s) -
Iola Pattabang,
Sunny Wangko
Publication year - 2013
Publication title -
jurnal biomedik : jbm
Language(s) - English
Resource type - Journals
eISSN - 2597-999X
pISSN - 2085-9481
DOI - 10.35790/jbm.1.1.2009.807
Subject(s) - hepatic stellate cell , cirrhosis , kupffer cell , sinusoid , perisinusoidal space , biology , chemistry , pathology , medicine , hepatocyte , biochemistry , in vitro
Hepatic stellate cell was firstly described by Carl von Kupffer in 1876 by using glod chloride staining. Stellate cells are found in spaces of Disse, that are located between hepatocytes and sinusoid endothelial cells. The main function of stellate cells is as vitamine A-storing cells. In liver cirrhosis, these stellate cells are activated and become proliferative, fibrogenic, and contractile myofibroblasts. Keywords: hepatic stellate cell, activated, cirrhosis Abstrak: Sel stelata hepatik pertama kali dideskripsikan oleh Carl Von Kupffer pada tahun 1876 dengan menggunakan metode pewarnaan gold chloride. Sel stelata terletak dalam celah Disse, yaitu celah antara hepatosit dan sel endotel sinusoid. Fungsi utama dari sel stelata ialah menyimpan vitamin A. Pada sirosis hepatis sel stelata akan teraktivasi menjadi miofibroblas yang bersifat proliferatif, fibrogenik dan kontraktil. Kata kunci: sel stelata hepatik, teraktivasi, sirosis