Open AccessInfectious complications and their contributing risk factors after allogeneic hematopoietic stem cell transplantation
Author(s) -
Mobil Akhmedov,
Galina Klyasova,
Е Н Паровичникова
Publication year - 2022
Publication title -
gematologiâ i transfuziologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-3042
pISSN - 0234-5730
DOI - 10.35754/0234-5730-2022-67-1-90-107
Subject(s) - hematopoietic stem cell transplantation , medicine , hypogammaglobulinemia , transplantation , neutropenia , stem cell , immunology , hematopoietic stem cell , disease , graft versus host disease , haematopoiesis , intensive care medicine , biology , chemotherapy , antibody , genetics
. Infections are among the most common complications after allogeneic hematopoietic stem cell transplantation. Aim — to provide a literature review on the main characteristics of infectious complications after allogenic hematopoietic stem cell transplantation and risk factors for their development. Main findings . Apart from direct factors such as neutropenia, hypogammaglobulinemia, and lymphopenia, there are indirect transplant-related factors such as conditioning regimen, transplant source, donor type, and graft-versus-host disease prophylaxis associated with higher infectious risk posttransplant. This review also presents the main characteristics of infections after allogeneic hematopoietic stem cell transplantation with a focus on bloodstream infections and provides an overview of the main transplant-related risk factors linked to their development.