Open AccessClonal hematopoiesis and its role in the development of hematological diseases
Author(s) -
Nataliya Petinati,
Drize Ni
Publication year - 2021
Publication title -
gematologiâ i transfuziologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-3042
pISSN - 0234-5730
DOI - 10.35754/0234-5730-2021-66-4-580-592
Subject(s) - haematopoiesis , immunology , myeloid , biology , somatic evolution in cancer , myeloid leukemia , progenitor cell , clone (java method) , hematological disorders , cancer research , stem cell , genetics , cancer , gene
. The formation of blood cells in a healthy individual is ensured by polyclonal hematopoiesis. Recent studies have shown that with age, large clones with a common genetic marker are found in the peripheral blood, i. e. cells originating from a single progenitor cell. This phenomenon is called clonal hematopoiesis. In some cases, people with clonal hematopoiesis develop hematological diseases. Aim — to describe and summarize current data on the relationship between clonal hematopoiesis and hematological diseases. Main findings . This review describes the history of detection of clonal hematopoiesis, its main properties, the most frequent mutations in hematopoietic clones associated with the risk of transformation into myelodysplastic syndrome, and acute myeloid leukemia. The meaning and possible pathogenesis of tumor transformation are discussed.