Open AccessThe frequency of detection of anti-HBc in blood donors from four regions of Russia
Author(s) -
Р. Р. Абакаров,
Д. С. Тихомиров,
Т. А. Туполева,
Е. Н. Игнатова,
С. М. Куликов,
T.Ts. Garmaeva,
Lara Tkachenko,
Ф. И. Сейтибрагимов,
Р. Г. Гильмутдинов,
Н. А. Мостовая,
О. Г. Македонская,
Т. В. Ромашкина,
Ludmila Davydova,
В. В. Герасимова,
Т. В. Гапонова
Publication year - 2021
Publication title -
gematologiâ i transfuziologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-3042
pISSN - 0234-5730
DOI - 10.35754/0234-5730-2021-66-2-242-252
Subject(s) - medicine , antibody , serology , antigen , titer , hepatitis b virus , blood transfusion , blood donor , occult , virology , immunology , virus , pathology , alternative medicine
. Occult hepatitis B virus (HBV) revelation in HBV nuclear antigen testing is of particular importance to prevent transfusion infection. Aim — the identification of factors affecting the anti-HBc detection rate in donated transfusable blood components from different regions of Russia. Materials and methods . A cohort screening single-stage epidemiological study was conducted with 2,000 donor blood samples, 500 samples per each of four regions of the country, the Republics of Crimea (Simferopol) and Sakha (Yakutia), the cities of Saransk and Orenburg. Data on 968 blood samples from the National Research Center for Hematology’s donor bank were used as reference. The testing targeted HBV nuclear antigen antibodies. Positive donated blood samples were additionally tested for IgM and virus surface antigen antibodies using Abbott and Vector-Best commercial reagent kits. Results . Donor demographic profiles differed insignificantly across members of the Russian Federation. Males predominated among the donors (69.6 %). Anti-HBc was detected in 219 of 2,000 samples examined (10.9 %). The donor blood sample anti-HBc detection rate ranged from 6.0 to 21.6 %, depending on the region. Anti-HBc-positive proportions in Orenburg, Crimea, Mordovia and Sakha comprised 8.2, 8.0, 6.0 and 21.6 %, respectively (p 100 mIU/mL) and in 5.0 % samples with their low or zero levels. In Yakutian donors, acute phase antibodies were revealed only at protective antibodies negative. In Saransk, this marker was equal-proportion at zero and high-titre protective antibodies (3.3 % each). Conclusion . Transfusion component procurement from younger donors should be prioritised as enhancing haemotransfusion viral safety. Positive occult HBV tests were less common in regions with low HBV incidence.