Open AccessWhole-body magnetic resonance imaging for diagnosis and treatment monitoring in multiple myeloma
Author(s) -
Natalia S Lutsik,
Larisa Mendeleeva,
Maxim Solovev,
С. М. Куликов,
Yulia Chabaeva,
G. A. Yatsyk
Publication year - 2020
Publication title -
gematologiâ i transfuziologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-3042
pISSN - 0234-5730
DOI - 10.35754/0234-5730-2020-65-4-431-443
Subject(s) - medicine , multiple myeloma , magnetic resonance imaging , diffusion mri , bone marrow , nuclear medicine , radiology , whole body imaging , chemotherapy , effective diffusion coefficient , pathology
. Whole-body diffusion-weighted magnetic resonance imaging (MRI) is an informative method for bone marrow inltration diagnosis in patients with multiple myeloma (MM) and post-monitoring in autologous haematopoietic stem cell transplantation (auto-HSCT). Aim : to study bone marrow lesions in MM patients using whole-body MRI prior to and after chemotherapy with subsequent auto-HSCT. Materials and methods . Forty patients with MM were included in a prospective study of whole-body MRI before and after high-dose chemotherapy with auto-HSCT. All patients had whole-body MRI prior to and at +100 day of auto-HSCT. Antitumour response was assessed after induction and at +100 day. The number and volume of bone marrow lesions prior to and at +100 day of auto-HSCT were determined, along with apparent diffusion coefcient (ADC) in the lesions. Results . We observed a signicant reduction of 29 % in the number of lesions, 40 % — in their volume and 33 % — in ADC. A signicant correlation was revealed between relative reduction in the number and volume of foci ( r = 0.52, p = 0.0017). A correlation was found between relative reduction in the foci number and ADC ( r = 0.47, p = 0.016). Patients with lesions > 7 cm 3 in MRI data exhibited a lesser reduction in the foci number and volume and ADC values after auto-HSCT compared to patients with lesions < 7 cm 3 . Conclusion . Whole-body MRI with diffusion-weighted imaging and subsequent estimation of the number and volume of lesions and their ADC values prior to and after auto-HSCT add power to assessing antitumour response in MM patients with auto-HSCT.