Open AccessThe role of interleukin-3 and its receptor in acute leukemia pathogenesis
Author(s) -
Я. Б. Бальжанова,
В. Г. Савченко
Publication year - 2020
Publication title -
gematologiâ i transfuziologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-3042
pISSN - 0234-5730
DOI - 10.35754/0234-5730-2020-65-3-335-350
Subject(s) - haematopoiesis , interleukin 3 receptor , leukemia , cytokine , biology , receptor , cytokine receptor , progenitor cell , cancer research , immunology , interleukin 3 , microbiology and biotechnology , stem cell , interleukin 21 , t cell , immune system , genetics
. Interleukin-3 (IL-3) is the key cytokine involved in the regulation of normal haematopoiesis. Some leukemic cells demonstrate high expression of the α-subunit of the receptor for interleukin-3 (CD123). Aim: to summarize the current understanding of IL-3 and its receptor CD123 in the pathogenesis of acute leukemia. General fi ndings : IL-3 regulates the proliferation and differentiation of normal hematopoietic progenitor cells in the early stages of hematopoiesis. The IL-3 receptor (CD123) is expressed on normal hematopoietic cells. High expression of CD123 was confi rmed on blast cells of AML, B-ALL and on the leukemia-initiating CD34+ CD38– cells. IL-3 inhibits apoptosis and promotes the autonomous growth of blast cells. Currently, different approaches of blocking the IL-3 mediated signal are being investigated.