Open AccessTHERAPY OF THE RESISTANT FORMS OF SUBCUTANEOUS PANNICULITIS-LIKE T-CELL LYMPHOMA
Author(s) -
Liliya Gorenkova,
С. К. Кравченко,
М. А. Силаев,
Н В Рыжикова
Publication year - 2019
Publication title -
gematologiâ i transfuziologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-3042
pISSN - 0234-5730
DOI - 10.35754/0234-5730-2019-64-3-353-361
Subject(s) - medicine , gemcitabine , panniculitis , lymphoma , immunophenotyping , chemotherapy , oncology , dermatology , pathology , immunology , flow cytometry
. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) belongs to a rare group of skin lymphoproliferative disorders, which is characterised by panniculitis-like clinical manifestations, the α/β cytotoxic immunophenotype of tumour cells, as well as a multidirectional course from indolent to aggressive forms. Aim . To examine patients with SPTCL having an aggressive clinical course and characterised by refractoriness to several lines of chemotherapy. Results . We present two case reports of patients with a generalised lesions and unfavourable prognostic factors, who achieved complete long-term remission of the disease as a result of gemcitabine chemotherapy. Conclusion . Despite the fact that both observed SPTCL patients demonstrated refractoriness to at least three types of treatment, the use of gemcitabine allowed long-term complete remissions of the disease to be achieved.