Open AccessBSM1 Polymorphism Association in Vitamin D Receptor Genes with the Occurrence of Colorectal Cancer in Palembang, Indonesia
Author(s) -
M. Alsen Arlan,
Sarup Singh,
Efman E.U. Manawan,
M. Hafidh Komar,
Irsan Saleh
Publication year - 2020
Publication title -
xi'nan jiaotong daxue xuebao
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.308
H-Index - 21
ISSN - 0258-2724
DOI - 10.35741/issn.0258-2724.55.6.8
Subject(s) - colorectal cancer , genotype , calcitriol receptor , allele , medicine , restriction fragment length polymorphism , allele frequency , exact test , polymerase chain reaction , gene , gene polymorphism , gastroenterology , oncology , cancer , biology , genetics , receptor
This paper analyzed the association between Bsm1 polymorphism in vitamin D receptor genes with colorectal cancer patients in Palembang, Indonesia. This case control study was conducted from June 2019 to December 2019. The genotype was analyzed using polymerase chain reaction-restriction fragment length polymorphism with the Bsm1 restriction enzyme. Findings showed the distribution of BB-Bb-bb genotype among colorectal cancer patients was 18.6%:26.7%:4.7%, whereas the distribution in a control group was 0%:43%:7%. The distribution of B and b alleles in colorectal cancer patients was 32%:18% compared to the control group’s distribution of 21.5%:28.5%. A statistical analysis of Fisher's exact test was conducted to examine the association of polymorphism with colorectal cancer occurrence. Findings demonstrated that there is a significant association was found between Bsm1 polymorphism of vitamin D receptor genes and colorectal cancer occurrences among patients in Palembang, Indonesia. Detailed analysis revealed that rs1544410 in the genotype BB might be a causal factor for colon cancer occurrence. Allele B on the other hand was reported to be the protective factor against colon cancer.