Open AccessPolymorphism of C/T-13910 lactase gene and anthropometric data of girls born in Samara
Author(s) -
Н. В. Спиридонова,
Спиридонова Наталья Владимировна,
Olga V. Sazonova,
Olga V. Sazonova,
A. A. Bezrukova,
A. A. Bezrukova
Publication year - 2019
Publication title -
nauka i innovacii v medicine
Language(s) - English
Resource type - Journals
eISSN - 2618-754X
pISSN - 2500-1388
DOI - 10.35693/2500-1388-2019-4-3-15-18
Subject(s) - genotype , samara , lactase , anthropometry , obesity , biology , genotype frequency , overweight , population , polymorphism (computer science) , body mass index , allele frequency , allele , genetics , medicine , endocrinology , gene , lactose , environmental health , ecology , biochemistry
Objectives -to assess the prevalence of C/T-13910 polymorphism of the lactase gene in the population of children in Samara and to identify the relationship with height, body weight and body mass index. Material and methods. The study included 103 girls aged 3-6 years. Their height and body weight were measured, and buccal samples were taken to genotype lactase activity (determining the C/T-13910 variant). Results. In girls born and living in Samara, the frequency of allele 13910-T was 48.6%. The СС genotype was detected in 51.4%, the СГ genotype in 37.9% and the TT genotype in 10.7%. There was no statistically significant relationship between genotype and body weight and height, but all children with the TT genotype had a height of more than 25 percentiles, the vast majority of overweight and obese girls (91%) had the СС genotype or the CT genotype.