Open AccessNEW APPROACH TO ASSESSMENT AND CORRECTION OF INTESTINAL MICROBIOME IMBALANCE IN CHILDREN WITH ATOPIC DERMATITIS
Author(s) -
Д.В. Печкуров,
Печкуров Дмитрий Владимирович,
O.N. Zaynullina,
Зайнуллина О. Н,
A.A. Tyazheva,
А. А. Тяжева,
A. V. Lyamin,
Лямин А. В
Publication year - 2019
Publication title -
nauka i innovacii v medicine
Language(s) - English
Resource type - Journals
eISSN - 2618-754X
pISSN - 2500-1388
DOI - 10.35693/2500-1388-2019-4-1-53-57
Subject(s) - dysbiosis , atopic dermatitis , microbiome , feces , medicine , gastroenterology , immunology , atopy , gut flora , allergy , biology , bioinformatics , microbiology and biotechnology
Objectives - to study intestinal microbiota species for differentiated approach to treatment of atopic dermatitis (AD) in children. Material and methods. The study included 60 children, 34 girls and 26 boys aged from 3 to 12 years, with AD and concurrent intestinal dysbiosis. The experimental group consisted of 30 children assigned to differentiated correction of intestinal microbiome imbalance in addition to the standard therapy. Correction mode depended on the results of microbiological fecal examination of microbiota species using the mass spectrometry. The control group of 30 children received the standard treatment of atopic dermatitis. Results. Gut microbiome imbalance of different severity was revealed in all children with AD. The study ascertained the increase of the enterobacteria of various types, including true pathogenic ones, in atopic dermatitis. The direct correlation was revealed between the AD severity and the degree of dysbiosis with the coefficient value 0.69. As a result of complex treatment in the experimental group, the ratio of children with severe dysbiosis reduced from 60.0% to 20.0%, the proportion of children with moderate dysbiosis also decreased from 26.6% to 20.0%. The reduced treatment time was one of the study outcomes: 14 days in the experimental group and 21 days in the standard therapy group. Clinical remission was observed in 26.7% of children. Conclusion. The study supported the rationale for the differentiated approach to the treatment of AD in children. The preliminary microbiological study of feces for microbiota species by MALDI-ToF mass spectrometry is necessary. Selection of probiotics depends on the deficit or overbalance of the specific types of microorganisms in a patient. Thus the treatment effectiveness is improved and the remission period is extended.