Open AccessDesign and Characterization of Sustained Release Tablet Formulation Containing Metformin Hydrochloride and Simvastatin
Author(s) -
Shankar Dhobale,
Sayali Nilakh,
Suresh Jadhav
Publication year - 2022
Publication title -
indo global journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 2249-1023
DOI - 10.35652/igjps.2022.12013
Subject(s) - simvastatin , metformin hydrochloride , dosage form , pharmacology , angle of repose , metformin , chromatography , solubility , drug , pharmaceutical formulation , chemistry , dissolution , medicine , materials science , diabetes mellitus , organic chemistry , composite material , endocrinology
The aim of the present work was to develop pharmaceutical combinational dosage form for simultaneous treatment of patients with type 2 diabetes with at high-risk of coronary disease associated co-morbidities. Metformin, an antidiabetic drug is used to treat the diabetic patient and combined with Simvastatin which is HMG-CoA reductase inihibitor drug to treat the high-risk coronary disease simultaneously. In this formulation, three batches were prepared by the direct compression method. Preformulation parameters such as identification, solubility, melting point, compatibility studies, Pre-compression parameters such as bulk density, tapped density, angle of repose, Hausner ratio, compressibility index, and Post-compression parameters like weight uniformity, hardness, drug content, thickness, in-vitrodrug release. In-vitrodrug release of all formulations, B1, B2, and B3 was carried out in 0.1N HCl for 2hrs and 10 hrs in phosphate buffer (pH 6.8) dissolution media. Among all the formulations, B3 was an optimized batch. B3 formulations showed drug release of 85% for Metformin Hydrochloride and 93% for Simvastatin over a period of 12hrs.©2022iGlobal Research and PublishingFoundation. All rights reserved.