Open AccessIntestinal alkaline phosphatase — a biomarker of the degree of acute enteralinsufficiency in urgent surgery
Author(s) -
Mikhail Topchiev,
Dmitry Parshin,
М. Ш. Мисриханов,
Stanislav Pyatakov,
Lev Brusnev,
Marat Chotchaev
Publication year - 2022
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2022/12/2.23
Subject(s) - alkaline phosphatase , medicine , gastroenterology , peritonitis , enteral administration , rank correlation , surgery , parenteral nutrition , biology , enzyme , biochemistry , machine learning , computer science
The diagnostic significance for levels of alkaline phosphatase (ALP) and intestinal alkaline phosphatase (IAP) and their ratio in blood serum and intestinal contents were compared to assess the degree of acute enteral insufficiency in urgent surgical pathology complicated by peritonitis. The results of examination of 112 patients with acute surgical pathology complicated by peritonitis were retrospectively analyzed. Biochemical data were compared with clinical and instrumental data obtained by ultrasonography and Doppler flowmetry. The main statistical indicator was Spearman's rank correlation coefficient, which showed a moderate direct correlation in patients with stage I and II enteral insufficiency (r=0.63 at p≤0.05), and in the group with st. III it showed a direct correlation with a high closeness of association (r=0.71 at p≤0.05). The IAP/ALP ratio makes it possible to objectively assess the severity of acute intestinal failure in urgent surgery