Open AccessStudy of the activity of the antioxidant system in experimental periodontitis
Author(s) -
Dalila Khaydar,
А. Н. Захватов,
Т. В. Тарасова,
V. Kozlov,
Vladislav Timoshkin,
Evgeniy Kalabkin,
Maya Timoshkina,
Liana Potapova
Publication year - 2022
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2022/12/1.21
Subject(s) - superoxide dismutase , catalase , antioxidant , periodontitis , hydroxyproline , chemistry , medicine , endocrinology , dentistry , biochemistry
The aim of this study was to evaluate the activity of the antioxidant system when creating a model of periodontitis in an experiment in rats. We made a model of periodontitis in rats (n = 10) by ligating the first two molars with a ligature. The control group consisted of intact rats (n = 10). In all animals, we determined the level of activity of catalase, superoxide dismutase and free hydroxyproline in blood plasma on the 3rd, 7th, 25th days. As a result, we revealed a significant decrease in the activity of enzymes of the antioxidant system in the main group compared with the control (p <0.001). Also, the rats of the main group had a negative correlation between the level of catalase (r = -0.84), and superoxide dismutase (r = -0.79) in relation to the parameters of free hydroxyproline. Conclusion: Low antioxidant status in rats with periodontitis leads to destruction of collagen structures in periodontal tissues.