Open AccessThe role of CD34-positive cells in the angiogenesis of malignant tissues
Author(s) -
Ivan Reva,
К В Стегний,
Е. Р. Двойникова,
Ekaterina Mozhilevskaya,
Marina Fleischman,
Stanislav Ichenko,
Valeriy Tolmachev,
Igor Sementsov,
Ellada Slabenko,
Dmitriy Zvyagintsev,
Gorbarenko Rodion,
A. N. Zolotov,
Т. Н. Обыденникова,
Galina Reva
Publication year - 2022
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2022/12/1.2
Subject(s) - angiogenesis , cd34 , malignancy , cancer research , pathology , medicine , regulator , biology , stem cell , microbiology and biotechnology , biochemistry , gene
Development of methods for targeted treatment aimed at inhibiting angiogenesis in malignant tissues is of great importance for modern oncology. The features of expression of CD34-positive cells at the border of the tumor and malignant tissue were studied. High expression of CD34-positive cells in small and large vessels during malignancy and is in correlation with the size of the tumor and the age of the disease. A promising target for targeted treatment is VEGF, as the main regulator of angiogenesis during tissue malignancy.