Open AccessCorrection of immobilization stress by melatonin in rats under conditions of dark deprivation
Author(s) -
Л. А. Балыкова,
Елена Андреевна Москаева,
В. И. Инчина,
Т. В. Тарасова,
Л. М. Мосина,
Olga Ignatieva,
Evgeniya Gvozdikova,
Dalila Khaydar,
А. В. Кучук,
И. В. Саушев
Publication year - 2022
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/6.8
Subject(s) - melatonin , placebo , medicine , endocrinology , placebo group , daylight , anesthesia , zoology , biology , pathology , physics , alternative medicine , optics
In this study, we have evaluated the effectiveness of melatonin in correcting stress in rats that occurred after dark deprivation and mobility restriction. The main group of animals (n=6) received melatonin in order to overcome stress. The obtained indicators for assessing the stress level (vertical activity, freezing, the number of boluses) in the main group of rats were compared with the indicators of the control (animals received placebo, n=6) and intact (n=6) groups. As a result, when the daylight lengthens, rats develop stress, which is manifested by a change in the activity of the animal. We have proved that the use of melatonin reduces hyperactivity in rats by 1.5 times (p<0.01) and the duration of freezing is reduced by ⅓ (p<0.05). Conclusion: In animals treated with melatonin, physical and vegetative activity was significantly higher compared to the placebo group. Therefore, melatonin helps to overcome immobilization stress in rats under conditions of dark deprivation.