Open AccessEffect of some biochemical factors on female reproductive function
Author(s) -
Natalya Igorevna Gudinskaya,
Oksana Boîko,
Rushaniya. Mukhamedzyanova,
Yuri Dotsenko,
Shakhrydin Tokhtarov,
Anzhela Ramaeva,
Galiya Khairulaeva,
Polina Gudinskaya
Publication year - 2021
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/6.7
Subject(s) - lactoferrin , fertility , medicine , endocrinology , c reactive protein , biology , physiology , inflammation , biochemistry , population , environmental health
The study aimed to determine the effect of certain biochemical factors on the female reproductive function. Analysis showed that two biochemical factors classified as inflammatory markers have a significant difference in their concentrations in women with impaired fertility and those without fertility disorders. These are C-reactive protein (CRP) and lactoferrin (LF). It is reasonable to assume that these inflammatory markers are associated to some extent with the development of reproductive disorders due to possible formation of inhibin A/LF complexes, which may reduce the biological activity of inhibin A, in patients’ serum. The effect of CRP on inhibin A activity is most likely to be systemic and associated with the effect of CRP high concentrations on inhibin A function on the body level. In particular, it is possible that CRP has an effect on IL-1βsynthesis in ovarian follicles.