Open AccessConcept of the influence of SARS -COV-2 viruses on cell malignancy
Author(s) -
Ivan Reva,
Tatsuo Yamamoto,
Galina Reva,
Dmitriy Zvyagintsev,
Viktor Usov,
Ekaterina Mojilevskaya,
Nikita Yupatin,
Е. Р. Двойникова,
M. Yu. Fleishman,
Ellada Slabenko,
Sergey Tseluiko,
Yuriy Krasnikov,
Yana Dolganina,
Igor Sementsov,
Valeriy Tolmachev,
Aleksandr Zolotov,
К В Стегний
Publication year - 2021
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/4.9
Subject(s) - biology , context (archaeology) , virology , virus , genome , disease , covid-19 , immunology , genetics , medicine , infectious disease (medical specialty) , gene , pathology , paleontology
To date, in the context of the COVID 19 pandemic, there are rumors and speculations about the consequences of the infection, as well as a concern on growing cancer risk due to vaccines and vaccination. In this study we reviewed the concepts of the viral action on cancer development and analyzed the data on the possibility of the malignant effect of the SARS-CoV-2 virus on cells. Analysis of the literature data showed that SARS-CoV-2 damages cells, like other viruses, but does not lead to their mutations. There are no changes in DNA, there is only misregulation of repression and expression of the genome, a perversion of signaling intercellular interactions that disrupt the mechanisms of differentiation and specialization of cells. The need of viruses to multiply in cambial cells of tissues contributes to the induction of their proliferation and the lack of specialization. Thus, the available information on the cytopathic effects caused by viruses in cells infected with COVID-19 does not yet provide information on the malignant effect of SARS-CoV-2. Our study is aimed at collecting and analyzing data that are necessary for planning effective treatment of patients with COVID 19 and predicting outcomes in the long term after the disease.