Open AccessGUM FLUID BIOMARKERS IN PERSONALIZED DIAGNOSTICS OF INFLA MMATOR Y PERIODONTAL DISEASES
Author(s) -
Larisa Ostrovskaya,
Oleg Eremin,
Natalia V. Zakharova,
Л. С. Катханова,
Artem Parfenov,
Julia Kobzeva,
Taisiya Kochkonyan,
Dmitry Domenyuk
Publication year - 2021
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/4.30
Subject(s) - periodontitis , medicine , periodontium , gingivitis , proinflammatory cytokine , inflammation , chemokine , cytokine , vascular endothelial growth factor , periodontal disease , gastroenterology , vegf receptors , pathology , dentistry
Aim of the study: To evaluate the diagnostic value of crevicular fluid immunoregulatory biomarkers in cases with inflammatory periodontal diseases. The study included a total of 97 patients aged 21 to 55 years with inflammatory periodontal disease (gingivitis — 22 patients; mild periodontitis — 31 patients; moderate periodontitis — 19) as well as 25 persons with healthy periodontium (the control group). A conventionally accepted clinical and instrumental examination revealed that all the patients with inflammatory periodontal diseases featured the most typical signs of periodontal issues: in the crevicular fluid — an increase in the levels of proinflammatory cytokines and chemokines (IL-1β, IL-6, IL-17, TNF-α), a decreased level of anti-inflammatory cytokine IL-1RA, and an increased concentration of vascular endothelial growth factor (VEGF). A ROC analysis showed that the increased content of VEGF, IL-8, IL-1β, IL-6 in the crevicular fluid is of a high diagnostic value in terms of detecting initial inflammation in the gum tissues, whereas the biomarkers pointing at periodontal destructive changes included high levels of VEGF, TNF-α and chemokines.