Open AccessEFFECT OF LEAD ON STRUCTURAL CHANGES IN LIVER OF WISTAR RATS UNDER THE CONDITIONS OF ACUTE EXPERIM
Author(s) -
O. A. Zayko,
В. В. Асташов,
Anna Sindireva,
Karina Basnakyan,
А. S. Luk'yanchikova
Publication year - 2021
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/2/4
Subject(s) - lead acetate , steatosis , lead (geology) , degeneration (medical) , lead poisoning , medicine , endocrinology , chemistry , pathology , toxicity , biology , paleontology , psychiatry
The purpose of this study was to evaluate the structural transformations of Wistar rats liver after oral administration of lead salts. Under the conditions of acute experiment during 5 days the Wistar rats were orally administered the lead acetate solution in the amount of 3 mg/kg. Histological studies were carried out at OSMU upon the completion of the experiment. Effect of toxic doses of lead causes symptoms of both steatosis and hydropic degeneration of the liver. It is assumed that the appearance of hepatic steatosis reflects the reaction of hepatocytes to hemic hypoxia caused by the action of lead, while the signs of hydropic degeneration expressed in varying degrees reflect its direct toxic effect.