Open AccessDEVELOPMENT OF A BIODEGRADABLE MATERIAL FOR BONE REGENERATION BASED ON SILICON COMPOUNDS
Author(s) -
Д. В. Компанцев,
Anna Chahirova,
Ruslan Yusupov,
Ilya Zaharchanko,
Natalia Shabanova
Publication year - 2021
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/2/25
Subject(s) - bone tissue , homogeneous , biomedical engineering , mineralization (soil science) , regeneration (biology) , materials science , soft tissue , bone structure , anatomy , chemistry , dentistry , pathology , biology , medicine , microbiology and biotechnology , mathematics , organic chemistry , combinatorics , nitrogen
In the course of this study we established that the laboratory sample in granulated form developed by us has a stimulating effect on the growth and proliferation of osteoblasts. Analysis of the data (CT, MRI) of the biological material obtained from the animals withdrawn from the experiment showed a statistically significant replacement of the artificial defect with bone tissue with signs of restoration of the cortical plate. The analysis of the CT results indicates that this method is sufficiently informative in assessing the regeneration of the trabecular structure of bone tissue. The study (MRI) of the bone material obtained from the animals participating in the experiment showed that when the osteoinductive material was integrated, the defect zone was replaced by 90%. In the projection of the defect, the newly formed tissue of a homogeneous structure was determined, corresponding in density to bone tissue with a high degree of mineralization. There was a complete restoration of bone tissue in the projection of the defect.