Open AccessThe role of environmental factors in the pathogenesis of cardiovascular diseases Part 1. Air Pollution
Author(s) -
Aleksey M. Chaulin,
D. V. Duplyakov
Publication year - 2021
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2021/11/1.5
Subject(s) - medicine , pathogenesis , intensive care medicine , mechanism (biology) , disease , population , bioinformatics , environmental health , immunology , pathology , biology , philosophy , epistemology
Background. Many factors and mechanisms are involved in the pathogenesis of cardiovascular diseases (CVD). Among them, as recent studies show, environmental factors play a vital role. At the same time a number of modern achievements in health care, including the improvement of early diagnosis and treatment methods for CVD has not significantly affected the rates of morbidity, mortality and disability in the population worldwide. This circumstance emphasizes the need to study the influence of additional factors, including environmental factors, in the fundamental processes of CVD pathogenesis and the subsequent translation of this knowledge into clinical practice. Goal. To study the effect of air pollution on the development and progression of cardiovascular diseases and discuss underlying causes. Methods. Analysis of modern international literary sources indexed in the PubMed / Medline and Embase databases. Results. Current clinical and experimental data support the relationship between air pollution with the risk of development and mortality caused by cardiovascular diseases. However, the pathophysiological mechanisms underlying this relationship are still underreported. It is believed that a vital role in the pathogenesis is played by endothelial dysfunction, increased thrombus formation, inflammatory processes and oxidative stress, which underlies the formation and progression of atherosclerosis, as well as an imbalance of the autonomic nervous system, which contributes to the development of arterial hypertension. Conclusion. According to the study, atmospheric air pollution has a significant impact on the pathogenesis of cardiovascular diseases. There is an urgent need for a further study of the specific pathogenetic mechanisms underlying the influence of these environmental factors on the development and progression of CVD to develop further treatment and prevention strategies to minimize the negative impact.