EFFECTS OF GLYPROLINES ON THE BEHAVIOR OF RATSIN THE PORSOLTTEST AND EXPERIMENTALLYINDUCED SOCIALS

In this work we studied the effect of glyprolines on the behavior of rats under conditions of experimental social stress. White male rats 6-8 months of age were used in the experiment. Throughout the experiment all animals were kept in standard-barrier conditions. The effect of glyprolines on the behavior of white male rats was studied on the model of social stress, implying that the animals are kept in conditions of a constant sensory contact. Glyprolines (Selank, Pro-Gly-Pro, Pro-Gly-Pro-Leu) were injected to the animals Intraperitoneally at a dose of 100 μg/kg/day within 20 days. Porsolt test was employed to carry out behavioral analysis in the animals. The outcomes revealed that regardless of the type of behavior (aggressive and submissive) in all the animals depression and anxiety disorders were developed, whereas Selank, Pro-Gly-Pro, Pro-Gly-Pro-Leu facilitated their alleviation. Thus, our experiment has demonstrated a psychomodulatory effect of the glyprolines.