Open AccessAntihypoxic activity of the VMA-10-18 derivate under hypobaric hypoxia in mice
Author(s) -
А В Геращенко,
Natalia Shabanova,
Andrey Voronkov
Publication year - 2020
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2020/10/4.6
Subject(s) - hypoxia (environmental) , chemistry , derivative (finance) , pharmacology , medicine , oxygen , organic chemistry , financial economics , economics
The present study was carried out to evaluate the effect of a new derivative VMA-10-18 (10 mg/kg) on the resistance of mice to acute hypobaric hypoxia. It was confirmed that the studied derivative contributes to an increase in the life time on the lethal test site by 2,7 times (p <0,05) compared with the control group of animals and exceeds the strength of the effect of the reference drug Metaprot by 1,2 (p <0,05).