Open Accessal deficits in experimental global cerebral ischemia in rats
Author(s) -
Natalia Shabanova,
А В Геращенко,
Andrey Voronkov
Publication year - 2020
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2020/10/4.5
Subject(s) - ischemia , neurological deficit , medicine , derivative (finance) , anesthesia , pharmacology , cardiology , business , finance
This study was aimed to assess the effect of a new pyrimidine derivative (PIR-12 50 mg/kg) on survival and neurological deficits in rat global brain ischemia. It has been confirmed that the investigated compound PIR-12 contributes to an increase in survival up to 80% and a decrease in neurological status by 73,3% compared to the control group of animals and exceeds the strength of the effect of the reference drug Cavinton by 30% and 22,48%, respectively.