Open AccessTHESIGNIFICANCE OF PHARMACOGENETIC TESTING FOR BETTER ANAESTHETIC OUTCOME AND LESSSURGICALSTRESS. Literature Review
Author(s) -
Kristina Tatzhikova,
Б. И. Кантемирова,
А В Жидовинов,
И. З. Китиашвили
Publication year - 2020
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2020/10/4.41
Subject(s) - pharmacogenetics , anesthetic , medicine , drug reaction , drug , drug response , anesthesia , allele , intensive care medicine , pharmacology , biology , genetics , genotype , gene
The review is devoted to the problem of optimizing the anesthetic manual based on pharmacogenetic data in order to achieve an adequate depth of anesthesia and stress protection and reduce the number of adverse drug reactions. We analyzed the data of Pub Med and Web of Science databases to investigate the influence of genetic polymorphism on the body's response to the main groups of drugs used for anesthesia, and changes in the effects of drug interaction. Specifically, we have reported that the use of preoperative genetic screening for a set of markers (polymorphic alleles of a number of cytochromes) is a promising tool in the anesthesiologist's practice.