Open AccessCLOZAPINE AND CLOZAPINE-ETHANOL POISONING AS A CAUSE OF HISTOMORPHOLOGICAL CHANGESIN THE CE
Author(s) -
Alexey Churilov,
А. М Голубев,
Д. В. Сундуков,
O. B. Romanova
Publication year - 2020
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2020/10/4.15
Subject(s) - clozapine , ethanol , cerebellum , medicine , anesthesia , pharmacology , toxicity , schizophrenia (object oriented programming) , chemistry , psychiatry , biochemistry
Clozapine is an atypical neuroleptic with a narrow therapeutic index which is widely used in clinical practice. Due to its psychotropic effect the drug is often misused. Experimental studies were performed on 25 outbreed mail rats. The animals were divided into 5 groups (the controls and four experimental groups). The controls included 5 intact rats. The experimental groups 1 and 2 were treated with clozapine at a dose 150 mg/kg. The experimental groups 3 and 4 received clozapine at the same dose and ethanol (2 ml/kg 70% ethanol). Severe damage to the Purkinje cells of the cerebellum was confirmed by an increase in the number of neurons that register signs of both reversible and irreversible damage. Purkinje cell alteration has increased by 24 hours from the beginning of the experiment.