Open AccessThe effect of PIR-9 compound on markers of apoptosis in experimental focal cerebral ischemia in rats
Author(s) -
Andrey Voronkov,
Natalia Shabanova,
М П Воронкова,
Т. А. Лысенко,
Alexander Arlt,
E.E. Zatsepina
Publication year - 2019
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2019/9/1/83
Subject(s) - apoptosis , ischemia , positive control , pharmacology , medicine , pyrimidine , derivative (finance) , chemistry , endocrinology , biochemistry , traditional medicine , financial economics , economics
A study to assess the effect of a newpyrimidine derivative (PIR-9 at a dose of 50 mg/kg) onapoptosis markers in experimental focal cerebral ischemiaof the rat brain. It has been confirmed that the investigatedcompound PIR-9 contributes to a decrease in theconcentration of TNFα by 34,36% (p<0,05) as comparedto that in rats treated with a reference drug Cavinton(3,2 mg/kg) and has an effect comparable in effect toGliatilin (60 mg/kg). The concentration of AIF in rats thatreceived compound PIR-9 was 29,99% (p<0,05) less than thegroup of negative control rats.