Open AccessPOSTMORTEM PATHOLOGICALFEATURES IN LIVER TISSUE OF HIV PATIENTS
Author(s) -
Mariya Tuchina,
Galina Reva,
Ivan Reva,
Vladimir Kozhukhar Kozhukhar,
Ruslan A. Nasyrov
Publication year - 2019
Publication title -
archiv euromedica
Language(s) - English
Resource type - Journals
eISSN - 2199-885X
pISSN - 2193-3863
DOI - 10.35630/2199-885x/2019/9/1/75
Subject(s) - hypoxia (environmental) , hemoglobin , cirrhosis , jaundice , hepatitis , medicine , pathology , ischemia , immunology , physiology , oxygen , chemistry , organic chemistry
Study of morbid anatomy material from deadpatients suffering from HIV-related illnesses, includinghepatitis С, provided an opportunity to identify substantialpathological changes in the structural elements liver thatsuggested other pathogenetic mechanism of developmentchanges in patients with HIV and hepatitis С associatedwith impaired metabolism in erythrocytes that arecollapsing, hemoglobin in the plasma of blood blood vesselsof the liver. As a result of the destruction of erythrocytes,free, not associated with erythrocytes, hemoglobincannot carry carbon dioxide from cells, hypoxia ensuesthe structural elements of the liver and cells are forcedto use the free dissolved in plasma oxygen, which furtherexacerbates the occurrence of hypoxia and Anoxia and thenthe appearance of intoxication of the massive destructionof hemoglobin and the advent of plasma transferrin. Thelast captured by macrophages. The free hemoglobin inthe bloodstream increases its toxic effect on tissue cells,causing cell death in the resultant ischemia, thus worseningthe oxygen supply of them. As a result of the subsequentdestruction of haemoglobin are formed its decay products inthe form of iron рorphyrin, bilirubin, The latter contributedto the development of jaundice or acute porfirii owing to thedeath of hepatocytes, which manifest is to develop cirrhosisor cancer