Open AccessDetection of Omic Markers of the Nervous System Adverse Effects in Children with a Combined Exposure to Airborne Chemicals and Conditions of Educational Environment
Author(s) -
Землянова Марина Александровна,
Н. В. Зайцева,
Yu.V. Koldibekova,
Н. И. Булатова
Publication year - 2020
Publication title -
zdorovʹe naseleniâ i sreda obitaniâ
Language(s) - English
Resource type - Journals
eISSN - 2619-0788
pISSN - 2219-5238
DOI - 10.35627/2219-5238/2020-326-5-12-17
Subject(s) - homeostasis , xylene , nervous system , physiology , medicine , toxicology , chemistry , biology , benzene , neuroscience , organic chemistry
The rationale of prognostic and predictive molecular biomarkers of malfunctioning of homeostatic control mechanisms is important for solving the tasks of early diagnosis and prevention of priority noncommunicable diseases. Our objective was to detect omic markers of adverse effects of a combined exposure to airborne contaminants and factors of educational environment on the nervous system of children. Materials and methods: We studied school outdoor and indoor concentrations of certain air pollutants, the intensity of the educational process, and plasma proteins characterizing nervous system adverse effects in children aged 7–10 with a combined exposure to various factors of educational environment in the primary school with various types of educational programs and hygienic conditions. Results: We established that blood manganese, nickel, lead, chromium, benzene, xylene, and phenol levels among the schoolchildren of the study group were 1.2–2.4 times higher than those in the control group. The phenol concentration in blood is a proven marker of the inhalation exposure. We also identified such violations of the educational process as uneven distribution of study loads, an increase in the maximum permissible load, a 1.2-fold increase in intellectual loads, shortening of the break between basic and optional classes, and a 1.5-fold increase in intensity of the training mode. We obtained mass spectra of the peptides reflecting changes in homeostasis on the molecular level. As a result of establishing a direct causal relationship between the increase in the relative mass of a Kazal-type 5 serine protease inhibitor, the increased blood phenol level, effects of intellectual loads, routine and distribution of the training load, the Kazal-type 5 serine protease inhibitor was proved to be an omic marker of the combined exposure to ambient phenol and the factors of educational environment. Conclusions: An increase in the relative mass of the Kazal-type 5 serine protease inhibitor following the combined exposure to airborne phenol and educational factors is a molecular indicator of its prognostically unfavorable involvement into the pathogenesis of functional disorders of the nervous system in the form of vegetative-vascular dystonia.