Open AccessANALYSIS AND EVALUATION OF BLOOD PLASMA PROTEOMIC PROFILE VIOLATIONS DUE TO THE INCREASED CONCENTRATION OF FLUORIDE ION IN CHILDREN’S URINE
Author(s) -
Н. В. Зайцева,
Marina А. Zemlyanova,
Н. И. Булатова,
Yu.V. Koldibekova
Publication year - 2019
Publication title -
zdorovʹe naseleniâ i sreda obitaniâ
Language(s) - English
Resource type - Journals
eISSN - 2619-0788
pISSN - 2219-5238
DOI - 10.35627/2219-5238/2019-316-7-23-27
Subject(s) - fluoride , urine , chemistry , ion , chromatography , biochemistry , inorganic chemistry , organic chemistry
We evaluated the air quality by the content of fluorine-containing compounds according to monitoring studies, chemical and analytical determination of fluoride ion in urine and performed proteomic analysis of blood plasma in children of the observation and comparison group. The increased content of fluoride ion in the urine was found in children of the observation group relative to the same indicator in children of the comparison group and the reference level in conditions of poor air quality for the hydrofluoride content due to the economic activity of aluminum production facilities. The concentration of fluoride ion in the urine is justified as a marker of inhalation exposure. A comparative analysis revealed the presence of significant differences in the relative volume of protein spots. Mass spectra were obtained that contain information about the peptides included in the composition of the studied protein set and the genes encoding identifiable proteins were established.