Open AccessPREVALENCE AND MOLECULAR GENETIC PECULIARITIES OF PARENTERAL VIRAL HEPATITIS B AND C AMONG HIVPOSITIVE CITIZENS OF THE FAR EASTERN FEDERAL DISTRICT, INCLUDING THOSE PERSONS SENTENCED TO DEPRIVATION OF FREEDOM
Author(s) -
Е. А. Базыкина,
V.B. Turkutyukov,
О. Е. Троценко,
В. О. Котова,
L.A. Balakhonsteva,
L.V. Varnavskaya,
В. В. Фоменко,
М. А. Чечулина
Publication year - 2019
Publication title -
zdorovʹe naseleniâ i sreda obitaniâ
Language(s) - English
Resource type - Journals
eISSN - 2619-0788
pISSN - 2219-5238
DOI - 10.35627/2219-5238/2019-311-2-51-55
Subject(s) - hbsag , medicine , coinfection , population , hepatitis b , viral hepatitis , genotype , hepatitis c , virology , immunology , human immunodeficiency virus (hiv) , hepatitis b virus , demography , biology , virus , environmental health , biochemistry , gene , sociology
We conducted a comparative analysis of the parenteral viral hepatitis B and C (HBV and HCV) prevalenceand their molecular genetic characteristics among prisoners of persons diagnosed with HIV infection (41samples), HIV-positive free citizens (187 samples) and «conditionally healthy population» with the lack ofinformation about the presence of a diagnosis of chronic viral hepatitis of any etiology and HIV infection(231 samples). Immunological and molecular biological research methods were used. Obtained data analysisshowed that the prevalence of infection markers with viruses of parenteral hepatitis was significantly higherin the groups of HIV-positive individuals (imprisoned and freemen). The HBsAg-negative form of thedisease was determined among the HIV-positive free population and in the «conditionally healthypopulation». Over the past 10 years (2009–2018), the proportion of HIV-positive prisoners in custody ofpeople with HCV monoinfection doubled, HBV was increased in 8.7 times. Significant decrease in thecombined infection of HBV and HCV of this contingent was found. Given this decrease in the penitentiarysystem in HIV-positive individuals, the overall burden of HBV infection (both in mono form and coinfectionwith HCV) significantly (5.3 times) decreased , which can be attributed to successful widespreadvaccination against hepatitis B in Russia. The most common HCV genotypes among HIV-positiveindividuals were 1b and 3a, genotypic structure of HBV prevailed genotype D.