Open AccessPARACETAMOL DRUG LOADED MICROCAPSULE BASED NANOFIBER PRODUCTION
Author(s) -
I.Y. Mol,
Funda Cengiz Çallıoğlu,
Hülya Kesici Güler,
M. Geysoğlu
Publication year - 2021
Publication title -
tex teh
Language(s) - English
Resource type - Journals
ISSN - 2068-9101
DOI - 10.35530/tt.2021.30
Subject(s) - nanofiber , materials science , electrospinning , viscosity , surface tension , composite material , chemical engineering , solvent , polymer , chemistry , organic chemistry , physics , quantum mechanics , engineering
In this study, it was aimed to production and characterization of paracetamol (PCT) loadedmicrocapsules and microcapsule added electro spun PVA nanofibers. Eudragit RS 100 and PVA were used asthe shell in the microcapsule structure, and PCT was used as the core material. First of all, the PCT loadedEudragit RS 100/PVA microcapsules were produced by solvent evaporation method under the optimum processparameters. Then, properties such as conductivity, viscosity and surface tension of the microcapsule loaded PVAsolution were measured and the effects of microcapsule concentration on the solution properties weredetermined. According to the solution results, while the viscosity increased with the microcapsule concentration,conductivity and surface tension did not change significantly except for the PVA-10 sample. After theelectrospinning process, fibre morphology was determined by SEM and incorporation of microcapsules into thenanofibers was clearly demonstrated. It was calculated from the SEM images that average microcapsule size is9.81μm, average fibre diameter is 550 nm and fibre diameter uniformity coefficient is 1.025. Finally, theincorporation of PCT loaded microcapsules into the nanofibers was chemically confirmed by FT-IR analysis. Itis thought that the results of this study will be useful for controlled drug release, especially in medical textiles.