Open AccessInvestigation the application of niosome as a nanocarrier for sage (Salvia officinalis L.) extract by spectroscopy and chemometrics
Author(s) -
Seyedeh Somayeh Samaei,
Mohammadreza Khanmohammadi Khorrami,
Amir Bagheri Garmarudi
Publication year - 2021
Publication title -
revista del cuerpo médico del hnaaa/revista del cuerpo médico hospital nacional almanzor aguinaga asenjo
Language(s) - English
Resource type - Journals
eISSN - 2227-4731
pISSN - 2225-5109
DOI - 10.35434/rcmhnaaa.2021.142.1044
Subject(s) - niosome , zeta potential , nanocarriers , fourier transform infrared spectroscopy , dynamic light scattering , salvia officinalis , chromatography , chemistry , chemometrics , materials science , sage , nanoparticle , nuclear chemistry , chemical engineering , analytical chemistry (journal) , nanotechnology , vesicle , biochemistry , membrane , physics , nuclear physics , engineering
Objetive: Investigation the application of niosome as a nanocarrier for sage (Salvia officinalis L.) extract by spectroscopy and chemometrics. Material and Method: In this study,niosome nanoparticles containing cholesterol and without cholesterol were prepared by thin film hydration method. Ethanol extract of sage was extracted by microwave and loaded inside the niosome nanoparticles. The size of the nanoparticles was determined by field imaging scanning electron microscopy (FE-SEM). The zeta potential of the niosomes was determined by Dynamic light scattering (DLS). to investigate the type of interactions between surfactants and cholesterol used in the niosome structure, Fourier transform infrared spectroscopy (FT-IR) was used. Drug release was investigated for 5 consecutive days in phosphate buffer salin (PBS) 0/01 M with pH=7.4 at T=370C. Results:The zeta potential of the niosomes with cholesterol and without cholesterol was -24/1&-15/6 mv . The loading capacity of the drug in the concentration range (1-3% w / w of niosum) for both types of niosome was between 61% and 93%. Conclusion: This results show that the release rate of niosme with cholesterol is significantly more regular and lower than of niosome without cholesterol. In general, it can be concluded that niosome can be a suitable nano-carrier for delivery of hydrophilic extract of the sage.