Open AccessThe periodontal diseases incidence in cases of the vdr gene polymorphism in patients with bronchocardial pathology
Author(s) -
Н.Ю. Ємельянова
Publication year - 2020
Publication title -
eksperimentalʹna ì klìnìčna medicina
Language(s) - English
Resource type - Journals
eISSN - 2710-1487
pISSN - 2414-4517
DOI - 10.35339/ekm.2019.01.03
Subject(s) - genotype , medicine , genotyping , allele , gene polymorphism , incidence (geometry) , calcitriol receptor , gastroenterology , disease , periodontitis , immunology , pathology , gene , genetics , biology , vitamin d and neurology , physics , optics
This paper presents the results of the study of the incidence and nature of periodontal diseases in cases of the VDR gene Taq1 polymorphism in patients with chronic obstructive pulmonary disease combined with coronary heart disease. It has been established that periodontal diseases are of multifactorial nature and have a genetic and phenotypic dependence. 144 patients were examined (115 people with chronic obstructive pulmonary disease combined with coronary heart disease and 29 patients with coronary heart disease). Complementary to clinical dental examination, there has been performed genotyping of T/C Taq1 T>t polymorphism (rs 731236) of the VDR gene using a polymerase chain reaction method. It has been noted that patients with coronary heart disease tend to have the TT genotype homozygotes more often if compared to the mutant C allele genotype. However, the primary group showed no differences between the TT and CC genotypes. It has been discovered that the patients of the primary group tend to have periodontal disease more often if compared to the group of patients with coronary heart disease. These results prove the need for future studies to develop methods for correction.