Open AccessPOSSIBILITIES OF THERAPY OF PAIN SYNDROME IN ENDOMETRIOSIS
Author(s) -
Yu. A. Dubossarskaya,
Z. M. Dubossarskaya,
Л.П. Грек
Publication year - 2021
Publication title -
zbìrnik naukovih pracʹ asocìacìï akušerìv-gìnekologìv ukraïni
Language(s) - English
Resource type - Journals
eISSN - 2707-1677
pISSN - 2664-0767
DOI - 10.35278/2664-0767.1(47).2021.242670
Subject(s) - medicine , endometriosis , estrogen , pelvic pain , anxiety , quality of life (healthcare) , fertility , visual analogue scale , disease , physical therapy , gynecology , gastroenterology , surgery , psychiatry , population , nursing , environmental health
Therapeutic tactics of endometriosis are aimed primarily at overcoming the pain syndrome, the absence of recurrence of the underlying disease, maintaining fertility and improving the psycho-emotional state of women. The objective to develop, pathogenetically substantiate treatment and rehabilitation measures taking into account pathogenetic preconditions in women with endometriosis in combination with pain. Materials and methods 85 patients with genital endometriosis with severe pelvic pain (VAS 7-10 points) (n = 44) - group I and moderate (VAS 4-6 points) (n = 41) - group II. The mean age of women in clinical trials I and II of the study was 37.71 ± 0.93 and 41.05 ± 1.08 (M ± m) years, respectively. The choice of treatment tactics was determined on the basis of immunohistochemical markers: estrogen receptors (ER), progesterone (PGR), proliferation index (Ki-67), vasculoendothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) in eutopic acid., psychoemotional characteristics and intensity of pelvic pain. Rеsultes of treatment in the examined patients a significant (p <0.05) reduction of pelvic pain was determined, both in the short and long term. After 6 months, the level of personal anxiety decreased - by - 38.62%, after 12 months. – at - 48.15% (p <0.05). The rate of decrease in the level of depressive disorders on the Hamilton scale of all studied women was: - 32.2% after 6 months and -42.15% after 12 months (p <0.05). Conclusion our approach to treating endometriosis helped to overcome pain in 83.53% of women, improve psycho-emotional and general condition, normalize sleep - was determined in 88.3% of women, reduce reactive anxiety and depressive disorders in 84.7% of patients, indicates the effectiveness proposed therapy.