Open AccessInduced pluripotent stem cells in periodontal regeneration - Narrative review
Author(s) -
Kumar Yadalam Pradeep
Publication year - 2020
Publication title -
jspir - journal of surgery, periodontology and implant research
Language(s) - English
Resource type - Journals
ISSN - 2184-4232
DOI - 10.35252/jspir.2020.1.002.1.06
Subject(s) - induced pluripotent stem cell , reprogramming , regeneration (biology) , sox2 , klf4 , stem cell , somatic cell , medicine , biology , microbiology and biotechnology , cell , embryonic stem cell , genetics , gene
Purpose: Periodontal disease is a severe infection caused by inadequate oral hygiene, resulting in tooth loss due to the bone destruction that supports the teeth. “Induced pluripotent stem cells” (iPSCs or iPS cells) is a sort of pluripotent stem cell that can be acquired out of adult somatic cells like peripheral blood mononuclear cells (PBMCs) or skin fibroblasts through inducing genetic reprogramming genes (Klf4, Oct4, c-Myc, and Sox2).Materials and Methods: This narrative review shows periodontal regeneration and bone regeneration using iPSCs and also highlights the drawbacks and challenges towards the future using iPSCs.Results and Discussion: Recent studies have shown greater regeneration when combination of iPSCs and enamel matrix derivates (EMD™) inserted into treatment of periodontal and bone defects. Conclusions: IPSC is a good alternative cell source in periodontal regeneration.