Open AccessNEW PERSPECTIVES IN TUMOR TREATMENT THROUGH USING NANOPARTICLES
Author(s) -
Daniel Argilashki,
Nina Koleva,
Bozhidarka Hadzhieva,
Desislava Bakova
Publication year - 2019
Publication title -
knowledge
Language(s) - English
Resource type - Journals
eISSN - 2545-4439
pISSN - 1857-923X
DOI - 10.35120/kij3404973a
Subject(s) - medicine , cancer , breast cancer , drug , chemotherapy , radiation therapy , disease , drug delivery , prostate cancer , paclitaxel , pharmacology , lung cancer , oncology , nanotechnology , materials science
Oncological diseases are one of the leading reasons of mortality in the last decade, despite the continued development of modern diagnostics and timely follow-up treatment. Cancer is a disease, characterized by the uncontrolled growth and spread of abnormal cells in the body. Tumor diseases are the second leading cause of death worldwide. In addition to surgical treatment or radiation therapy, chemotherapy is one of the main methods of treatment for patients with cancer. It attacks fast-growing cancer cells using chemicals. Chemotherapy drugs (antimetabolites, alkylating agents, drugs that disrupt DNA synthesis, hormonal drugs, etc.) also attack other healthy cells, which is a major drawback of this method of treatment. Conventional dosage forms have a number of disadvantages - low bioavailability, limited efficacy, poor tissue distribution of the drug substance, side effects. Another major difficulty is the development of drug resistance, which renders therapy ineffective. For these reasons, it is necessary to seek new methods and approaches for the introduction of these medicinal substances. In this review, we present current studies exploring the implementation of controlled drug delivery strategies using nanoparticles in some of the most common oncologic diseases worldwide such as breast cancer, prostate cancer, lung and liver cancer, pancreas and the ovaries cancer. The use of nanoparticles as drug carriers or as diagnostic agents provides new perspectives in the treatment of these cancers. Nanoparticles can improve the water solubility of a number of drugs, resulting in improved bioavailability. The administration of nanoparticles can also use to target antitumor therapy, leading to treatment that is more appropriate on the one hand and reducing adverse reactions on the other. For these reasons, a more in-depth study of the use of nanoparticles in tumor diseases is needed in order to be able to more fully explore their advantages and disadvantages.