Open AccessPARACETAMOL POISONING – REVIEW
Author(s) -
Olimpiada Atmazhova,
Evgenia Barzashka
Publication year - 2019
Publication title -
knowledge
Language(s) - English
Resource type - Journals
eISSN - 2545-4439
pISSN - 1857-923X
DOI - 10.35120/kij3404859a
Subject(s) - acetaminophen , medicine , analgesic , antipyretic , drug , liver disease , anesthesia , pharmacology
Paracetamol (acetaminophen) is included in more than 200 medicines of various trade names, including numerous preparations for children used as analgesic and antipyretic drugs. Poisoning usually occurs after taking a large single dose of paracetamol or combination paracetamol-containing preparations, and as a result of prolonged use of paracetamol in smaller doses by persons with increased sensitivity, alcohol abuse, diet error, or in combination with drugs, which affect its metabolism in the liver. Paracetamol poisoning is among the intoxications that have a latent period. Clinical manifestations of acute poisoning develop in stages. The intensity of the initial symptoms does not always determine the outcome of the disease. Paracetamol poisoning is a common cause of liver damage and is a leading etiologic factor in acute liver failure. The worldwide spread of poisoning with this drug is epidemic.