Open AccessRelationship between intraocular, blood and cerebrospinal fluid pressures: a theoretical approach
Author(s) -
Giovanna Guidoboni,
Fabrizia Salerni,
Rodolfo Repetto,
Marcela Szopos,
Alon Harris
Publication year - 2019
Publication title -
journal for modeling in ophthalmology
Language(s) - English
Resource type - Journals
eISSN - 2468-3930
pISSN - 2468-3922
DOI - 10.35119/maio.v2i3.93
Subject(s) - cerebrospinal fluid , cerebrospinal fluid pressure , papilledema , glaucoma , intraocular pressure , medicine , aqueous humor , blood pressure , intracranial pressure , ophthalmology , anesthesia
Intraocular pressure (IOP), arterial blood pressure (PA), and cerebrospinal fluid (CSF) pressure have been identified as major players in several ocular pathologies, including glaucoma, central vein occlusion, and papilledema, to name a few. IOP, PA, and CSF pressures are not independent from each other. For example, aqueous humor and CSF flows, whose mechanics contribute to establish IOP and CSF pressure levels, originate from blood flow, which is driven by PA. As a consequence, it is difficult to experimentally isolate IOP, PA, and CSF pressure and to disentangle their effect in pathological conditions. Here we utilize a theoretical approach to address this issue.