Open AccessEpstein-Barr virus uveitis after intravitreal triamcinolone injection
Author(s) -
Jessica Ong,
Jeffrey Colin Richards
Publication year - 2021
Publication title -
asian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 5
eISSN - 2452-0691
pISSN - 1560-2133
DOI - 10.35119/asjoo.v17i4.616
Subject(s) - medicine , macular edema , triamcinolone acetonide , uveitis , ophthalmology , mononucleosis , intermediate uveitis , prednisolone , corticosteroid , methylprednisolone , bevacizumab , surgery , virus , retinal , virology , chemotherapy , anterior uveitis
Purpose: To report a case of Epstein-Barr virus (EBV) uveitis after intravitreal triamcinolone injection.
Methods: Observational case report.
Results: A 66-year-old male presented with bilateral intermediate uveitis, left macular branch retinal vein occlusion, and left macular edema 3 months following acute infectious mononucleosis. He received systemic prednisolone, methotrexate, and intravitreal bevacizumab with partial response. Intravitreal triamcinolone was given for recurrent macular edema, which led to the development of severe panuveitis with positive EBV PCR in aqueous humour. This was successfully treated with high-dose systemic valaciclovir and topical prednisolone.
Conclusion: Non-infectious uveitis may become infectious following intravitreal steroid administration triggering intraocular viral replication. Intraocular fluid should be tested in cases which are suspicious for infection and EBV should be considered a differential diagnosis, particularly if PCR is negative for more common viral etiologies.