Open AccessQuiral Inversion of Ibuprofen after an Oral Administration Under Complete Fasting and Fed Conditions in Caucasian Healthy Subjects
Author(s) -
Marianela Lorier,
Pietro Fagiolino,
Marta Vázquez,
Manuel Ibarra,
Natalia Guevara
Publication year - 2021
Publication title -
global journal of science frontier research
Language(s) - English
Resource type - Journals
eISSN - 2249-4626
pISSN - 0975-5896
DOI - 10.34257/gjsfrbvol21is2pg1
Subject(s) - ibuprofen , crossover study , regimen , medicine , anesthesia , pharmacology , alternative medicine , pathology , placebo
Background: The aim was to determine the effect of feeding on chiral inversion of Ibuprofen isomers. Method: Six healthy volunteers participated in a two-treatment crossover study where a single dose of Ibuprofen racemate was given. One stage consisted in an 8-hour interval of fasting, while in the other, the drug was administered with a solution of saccharose and a standard food intake regimen was implemented.