Open AccessEfficient and Facile One-Pot Synthesis of Novel Benzimidazoles using Rice Husk
Author(s) -
Suman Suman,
Rajvir Singh,
Susheel Gulati,
Suprita Suprita
Publication year - 2020
Publication title -
global journal of science frontier research
Language(s) - English
Resource type - Journals
eISSN - 2249-4626
pISSN - 0975-5896
DOI - 10.34257/gjsfrbvol20is1pg27
Subject(s) - husk , yield (engineering) , benzaldehyde , melting point , fourier transform infrared spectroscopy , catalysis , chemistry , reaction conditions , atom economy , nuclear chemistry , materials science , organic chemistry , chemical engineering , metallurgy , botany , engineering , biology
New and facile one-pot approach for the synthesis of substituted benzimidazoles from the reaction of substituted benzaldehyde and o-phenylenediamine room temperature using Rice Husk Ash: CaCl2 (RHA:CaCl2) as a green catalyst was presented in the paper. After the completion of the reaction, the reaction mixture was poured into ice-coldwater with stirring, and the precipitated product was filtered using the filter pump. The crude product was then recrystallized from ethanol to give analytically pure samples in good to excellent yield. The purity of compounds were characterized by melting point and thin-layer chromatography. The synthesized compounds were characterized by using 1HNMR and FTIR spectral techniques.Metal-free, short reaction time, high yields, mild reaction condition, simple work-up, high atom economy, cost-effectiveness, and no need for column purification are some beauties of this methodology.