Open AccessKey factors of inflammation and long-term prognosis in patients with myocardial infarction and visceral obesity
Author(s) -
Evgenya Uchasova,
Е. В. Белик,
О. В. Груздева,
Yu. A. Dyleva,
А. А. Кузьмина
Publication year - 2020
Publication title -
tihookeanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
ISSN - 1609-1175
DOI - 10.34215/1609-1175-2020-3-77-82
Subject(s) - proinflammatory cytokine , medicine , obesity , myocardial infarction , inflammation , tumor necrosis factor alpha , c reactive protein , gastroenterology , interleukin 6 , systemic inflammation , cardiology
Objective: To assess the relation between key factors of inflammation and myocardial infarction complications in different stages of the diseases in patients with visceral obesity. Methods : Men with the diagnosed myocardial infarction were examined: 64 of them with visceral obesity (the first group) and 30 of them without visceral obesity (the second group). On the 1s t and 12th day of hospitalization, the serum concentrations of interleukins (IL) 1β, 6, 8, 10 and 12, tumor necrosis factor α (TNFα) and C-reactive protein (CRP) were determined. The control group included 30 healthy men. Results : The cytokine profile in visceral obesity was characterized by the increase in concentration of proinflammatory ILs and the decrease in concentration of IL-10. The concentration increase was: 1.3 times for IL-1 and TNFα, 2 times for IL-12, 6 times for IL-6 and 24 times for IL-8 and CRP. The increase in IL-6 and CPR levels in blood serum was associated with the obesity. Conclusions : The development of adverse cardio‑ vascular complications a year later after the previous myocardial infarction is typical for patients with visceral obesity and is followed by the activation of proinflammatory cytokines and deficiency of IL-10.