Morphometric and topograpical analysis of retinal abnormalities in central serous chorioretinopathy

Objective : Quantitative morphometric and topographic analysis of specific changes of the retina in patients with the acute central serous chorioretinopathy (CSC) based on annotated tomograms. Methods : 39 patients with the acute CSC (44 eyes – 45 scans) were examined. A complex ophthalmological examination was carried out including 3D optical coherence tomography of maculae. The data was uploaded into CVAT. Three classes of pathological changes were differentiated: 1) retinal neuroepi‑ thelium detachment; 2) retinal pigment epithelium alteration; 3) percolation zones. The analysis of topographical localization of changes and their morphological relations were assessed with a programming language Python. Results : A moderate trend towards vertical asymmetry of the neuroepithelial detachment zone with an excess of cumulative distribution in the lower part of the macula was revealed. Retinal pigment epithelium alteration sites and percolation zones demonstrated a relative peak of representation in the upper nasal part of the macula. In 69.9% and 80% of cases, respectively, abnormalities of retinal pigment epithelium and percolation zones were localized within the limits of neuroepithelial detachment. Direct correlation between the area of neuroepithelial detachment and the area of percolation zones; the area of percolation zones and the area of retinal pigment epithelium alteration; the area of neuroepithelial detachment and the area of retinal pigment epithelium alteration. Conclusions : Percolation zones and abnormalities of retinal pigment epithelium demonstrate similar trends in topo‑ graphical localization and quantitative characteristics and are related to the area of neuroepithelial detachment in CSC. Thus, the number of retinal pigment epithelium abnormalities can serve as an indicator of disease severity.