Open AccessMolecular and genetic mechanisms of endothelial dysfunction in children with allergic enteropathy
Author(s) -
Т. А. Шуматова,
Nelli G. Prihodchenko,
Е. С. Зернова
Publication year - 2019
Publication title -
tihookeanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
ISSN - 1609-1175
DOI - 10.34215/1609-1175-2019-4-32-35
Subject(s) - nitric oxide , enteropathy , endothelial dysfunction , immunology , allergy , nitric oxide synthase , allele , medicine , inflammation , allergic inflammation , endothelium , gene , biology , genetics , disease
Objective. The objective is to analyze molecular and genetic mechanisms of endothelial dysfunction development in children with allergic enteropathy. Methods: We have studied the polymorphisms of endothelial nitric oxide synthase gene and the level of nitric oxide metabolites in coprofiltrates in 43 children aged from 6 months to 3 years with allergic enteropathy. Results: The endothelial dysfunction in allergic enteropathy is associated with nitric oxide molecule. Carriage of the homozygous allele СС Т 786 С of the endothelial nitric oxide synthase gene raises the risk of IgE-independent food allergy development by 8.8 times. Conclusions: The conducted study evidences the active participation of nitric-oxidergic mechanism in allergic inflammation development.