Open AccessSerum Level of Galectin-3 in Early Detection of Acute Pancreatitis
Author(s) -
Samaneh Porozan,
Pezhman Alavinejad,
Javad Mozafari,
Hosein Kazem Mousavi,
Ali Delirrooyfard
Publication year - 2021
Publication title -
middle east journal of digestive diseases./middle east journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.146
H-Index - 2
eISSN - 2008-5249
pISSN - 2008-5230
DOI - 10.34172/mejdd.2021.246
Subject(s) - medicine , acute pancreatitis , galectin 3 , prospective cohort study , pancreatitis , emergency department , gastroenterology , diagnostic accuracy , hospital admission , emergency medicine , psychiatry
BACKGROUND Acute pancreatitis (AP) is a common cause of hospital admissions. Diagnosing AP in patients presenting to emergency departments remains a challenge for physicians. Thus, we aimed to evaluate the diagnostic accuracy of galectin-3 to find a new and effective method for detecting AP. METHODS In this prospective cross-sectional study, 43 patients with a manifestation of AP were enrolled. The serum levels of galectin-3 were measured at admission and 48 hours later and compared between the groups of patients with and without AP. RESULTS Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases compared with non-AP individuals. The area under the curve (AUC) for galectin-3 was 73.1%, which revealed a good accuracy in predicting the AP diagnosis. CONCLUSION Serum levels of galectin-3 at admission and after 48 hours were significantly higher in AP cases, and their diagnostic value was acceptable in the detection of AP.