Evaluating the influence of Citrullus lanatus seed extracts on electrolytes, urea and creatinine in Streptozotocin induced diabetic albino rats

The focus of current research study was to evaluate the influence of theseed extract of Citrullus lanatus on urea, creatinine, potassium, sodium,chloride and bicarbonate in streptozotocin induced diabetic rats.Eighteen male wistar albino rats were divided into six groups of threerats each, diabetes were induced in all the rats except group 1 by intraperitoneal injection of 45 mg/kg b.wt. of streptozotocin. Group 1 ratsserved as control and received standard feed and water daily; Group 2rats received oral Glibenclamide (0.5 mg/kg bw); Group 3,4, and 5received 200 mg/kg bw, 400 mg/kg bw and 600 mg/kg b.wt. of theethanolic extract of Citrullus lanatus seed respectively; and group 6served as diabetic group. Blood samples were collected and analysed forurea, creatinine, potassium, sodium, chloride and bicarbonate usingurease-Berthelot colorimetric method, Jaffe’s colorimetric method andIon selective electrode (ISE) method respectively. There was a significantdecrease in (p<0.05) glucose concentration (mmol/L) of 3.90 in controlcompared to 8.07, 8.73, 14.67, 11.43 and 9.80 in albino rats treated withglibenclamide, STZ+CLS 200 mg, STZ+CLS 400 mg, STZ+CLS 600 mg anddiabetic control respectively. In potassium concentration (meq/l) 6.51in control compared with 4.97, 7.59, 7.28, 8.45 and 6.87 in albino ratstreated with glibenclamide, STZ+CLS200 mg, STZ+CLS 400 mg, STZ+CLS600 mg and diabetic control respectively. While in sodium concentration(meq/l) of 1.42 in control compared to 1.33, 1.30, 1.36, 1.42 and 1.36in albino rats treated with glibenclamide, STZ+CLS 200 mg, STZ+CLS 400mg, STZ+CLS 600 mg and diabetic control respectively. However, inchloride concentration (meq/l) of 1.06 in control compared to 99.10,97.87, 1.04, 88.00, 1.04, 88.00 and 1.04 in albino rats treated withglibenclamide, STZ+CLS 200 mg, STZ+CLS 400 mg, STZ+CLS 600 mg anddiabetic control respectively and also in bicarbonate concentration(meq/l) of 10.07 when compared with 17.30, 16.47, 15.40, 6.40 and17.30 in albino rats treated with glibenclamide, STZ+CLS 200 mg,STZ+CLS 400 mg, STZ+CLS 600 mg and diabetic control respectively. Inconclusion, this medicinal plant could be considered as a potential andalternative approach for the treatment of diabetes.Keywords: Keywords: Citrullus lanatus, Diabetes Mellitus, Renal