Ibuprofen/β-CD complexation by controlled annealing of their mechanical mixture | Zendy

St. Pereva | Zendy; Ts. Sarafska | Zendy; Vesselin Petrov | Zendy; M. Spassova | Zendy; С. А. Богданова | Zendy; Тony Spassov | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Ibuprofen/β-CD complexation by controlled annealing of their mechanical mixture

Author(s) -

St. Pereva,

Ts. Sarafska,

Vesselin Petrov,

M. Spassova,

С. А. Богданова,

Тony Spassov

Publication year - 2019

Publication title -

bulgarian chemical communications

Language(s) - English

Resource type - Journals

ISSN - 0324-1130

DOI - 10.34049/bcc.51.3.4907

Subject(s) - ibuprofen , differential scanning calorimetry , cyclodextrin , fourier transform infrared spectroscopy , chemistry , molecule , annealing (glass) , powder diffraction , calorimetry , nuclear chemistry , chemical engineering , materials science , chromatography , organic chemistry , crystallography , thermodynamics , composite material , pharmacology , medicine , physics , engineering

Ibuprofen/β-cyclodextrin complex was formed applying a modified melting method, consisting in melting only the drug in the mechanical mixture of ibuprofen and β-cyclodextrin. The ibuprofen inclusion into β-CD was monitored by differential scanning calorimetry after initial release of the water molecules from the CD cavity and was proved by X-ray diffraction and FTIR analyses.Keywords: β-cyclodextrin, ibuprofen, inclusion complex, melting method

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research