Open AccessIbuprofen/β-CD complexation by controlled annealing of their mechanical mixture
Author(s) -
St. Pereva,
Ts. Sarafska,
Vesselin Petrov,
M. Spassova,
С. А. Богданова,
Тony Spassov
Publication year - 2019
Publication title -
izvestiâ po himiâ
Language(s) - English
Resource type - Journals
ISSN - 0324-1130
DOI - 10.34049/bcc.51.3.4907
Subject(s) - ibuprofen , differential scanning calorimetry , cyclodextrin , fourier transform infrared spectroscopy , chemistry , molecule , annealing (glass) , powder diffraction , calorimetry , nuclear chemistry , chemical engineering , materials science , chromatography , organic chemistry , crystallography , thermodynamics , composite material , pharmacology , medicine , physics , engineering
Ibuprofen/β-cyclodextrin complex was formed applying a modified melting method, consisting in melting only the drug in the mechanical mixture of ibuprofen and β-cyclodextrin. The ibuprofen inclusion into β-CD was monitored by differential scanning calorimetry after initial release of the water molecules from the CD cavity and was proved by X-ray diffraction and FTIR analyses.Keywords: β-cyclodextrin, ibuprofen, inclusion complex, melting method